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Donepezil Hydrochloride (Aricept) Nootropic Agent Powder for Alzheimer′s Disease

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99% Pharmaceutical powder Donepezil Hcl Powder

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Donepezil hydrochloride Donepezil Molecular Formula:C24H30ClNO3 Donepezil Formula Weight:415.95 Donepezil CAS:120011-70-3 Donepezil Purity:99% Donepezil Appearance:white powder Donepezil Introduction Donepezil hydrochloride is a therapeutic treatment of Alzheimer's drugs, compared with similar drugs have a low incidence of adverse reactions and efficacy obvious feature is the only way to reach the U.S. Food and Drug Administration standard treatment guidelines for Alzheimer's disease drug, is the only one species while the FDA approved the listing of new drugs and UK MCA for the treatment of mild to moderate Alzheimer's. Donepezil Function Mild or moderate Alzheimer-type dementia treatment. Donepezil hydrochloride is a long-acting Alzheimer's disease (AD) in the symptomatic treatment drugs. AD is a kind of memory loss as the main performance, accompanied by other cognitive impairment of acquired intelligence decline. Nearly 30 years of research show: AD progressive degeneration of cholinergic neurons is memory loss, disorientation, personality changes and behavioral reasons, such cholinergic theory has been confirmed by histological study. Donepezil hydrochloride is a second-generation cholinesterase (ChE) inhibitor, its therapeutic effect is reversibly inhibiting acid hydrolysis of acetylcholine acetylcholinesterase (AchE) caused by increased content of acetylcholine receptor sites. Donepezil may have other mechanisms, including the disposal of the direct effect of the peptide, neurotransmitter receptors, or Ca2 + channels. Donepezil hydrochloride selection of AchE affinity than to butyrylcholinesterase (BchE) 1250 times stronger, it can inhibit the brain tissue ChE, but on the heart (myocardium) or small intestine (smooth) had no effect, probably on the chest organization (rhabdomyosarcoma) role; on the central nervous toxicity than tacrine. Donepezil Application 1. adult / elderly: initial treatment dosage 5mg / day (day 1). The product should be orally at bedtime at night. Doses of 5mg / day should be maintained at least - months to evaluate early clinical response, and donepezil hydrochloride reach steady-state plasma concentrations. After using 5mg / day treatment a month, making clinical evaluation may be the product of the dose to 10mg / day (day 1). The maximum recommended dose is 10mg. Greater than 10mg / day dose clinical trials have not done. We did not conduct placebo-controlled clinical trials with more than six months. After stopping treatment, the efficacy of the product gradually diminishes. Discontinuation of treatment no rebound phenomenon. 2. liver and kidney damage: For mild to moderate renal and hepatic dysfunction, donepezil hydrochloride elimination is not affected, so these patients can use a similar dose schedule. The COA:

Product nameDonepezil hydrochloride

Synonyms2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride

CAS No.120011-70-3

Molecular formulaC24H29NO3.HCl

Molecular weight415.95

Specifications

ITEMSSPECIFICATIONSRESULTS

APPEARANCEWHITE OR ALMOST WHITE CRYSTALLINE POWDERCONFORMS

SOLUBILITYTO MATCH WORKING STANDARDCONFORMS

IDENTIFICATION1) BY UV ABSORPTION,TO MATCH WORKING STANDARD 2) BY IR ABSORPTION,TO MATCH WORKING STANDARDCONFORMS CONFORMS

PH4.0-7.05.47

MELTING POINT216-220°C218-220°C

RELATED SUBSTANCE

TOTAL≤1.80%0.07%

SINGLE IMPURITY (UNKNOWN)≤0.50%<0.1%

LOSS ON DRYING≤1.0%0.03%

RESIDUE ON IGNITION≤0.10%0.08%

HEAVY METAL≤10 PPM<10 PPM

ASSAY≥99.0%99.75%

CONCLUSIONCONFORMS TO THE ENTERPRISE STANDARD

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